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Neurological Disorders Now Top Cause of Illness Disability. (Part 2)

Updated: Apr 29

How can I lower my blood pressure and reduce my risk of Neurological Disease?

Presented by Metulas Supplements.


Harnessing the Power of L-Arginine and L-Citrulline: A Pathway to Lower Systolic Blood Pressure and Neurological Disease Prevention.

In the realm of cardiovascular health and neurological disease prevention, a natural compound known as nitric oxide (NO) has garnered significant attention. Nitric oxide plays a pivotal role in regulating blood pressure, vascular function, and neurological health. Emerging research suggests that the amino acids L-arginine and L-citrulline, precursors to nitric oxide synthesis, hold promise in reducing systolic blood pressure and mitigating the risks of neurological diseases. This blog explores the intricate connection between these amino acids, nitric oxide production, and their potential benefits in promoting overall health.

Understanding Nitric Oxide:

Nitric oxide, often termed the "miracle molecule," is a signalling molecule produced by the body that regulates various physiological functions. One of its key roles is vasodilation, the widening of blood vessels, which leads to improved blood flow and reduced blood pressure. Nitric oxide achieves this by relaxing the smooth muscle cells lining the blood vessels, thereby increasing their diameter and lowering resistance to blood flow.

L-Arginine: The Precursor to Nitric Oxide Synthesis:

L-arginine is a semi-essential amino acid, meaning it can be synthesized by the body but may also need to be obtained from dietary sources under certain conditions. Within the body, L-arginine serves as the primary substrate for nitric oxide synthesis. Through the action of nitric oxide synthase (NOS) enzymes, L-arginine is converted into nitric oxide and citrulline. This enzymatic process is crucial for maintaining cardiovascular health and overall well-being.

L-Citrulline: A Vital Player in Nitric Oxide Production:

While L-arginine is the direct precursor to nitric oxide, L-citrulline plays a complementary role in the nitric oxide synthesis pathway. Unlike L-arginine, L-citrulline is not utilized as readily by the body for nitric oxide production. However, it serves as a precursor to L-arginine through a process called the L-arginine-NO pathway. By replenishing L-arginine levels indirectly, L-citrulline helps sustain nitric oxide synthesis over a more extended period, contributing to enhanced vascular function and blood pressure regulation.

Reducing Systolic Blood Pressure through Nitric Oxide Modulation:

Elevated systolic blood pressure, the pressure in the arteries when the heart beats, is a significant risk factor for cardiovascular diseases such as hypertension, heart attack, and stroke. Nitric oxide's vasodilatory effects play a crucial role in lowering systolic blood pressure by promoting relaxation of the blood vessels. Studies have shown that supplementation with L-arginine and L-citrulline can increase nitric oxide levels, leading to improved endothelial function and reduced systolic blood pressure.

In a randomized controlled trial published in the American Journal of Hypertension, researchers investigated the effects of L-arginine supplementation on blood pressure in individuals with prehypertension. The study demonstrated that daily supplementation with L-arginine led to significant reductions in both systolic and diastolic blood pressure compared to a placebo group. These findings underscore the potential of L-arginine in managing hypertension and reducing the risk of cardiovascular events.

Furthermore, L-citrulline supplementation has also shown promising results in lowering blood pressure. A meta-analysis published in the Journal of Hypertension analysed multiple randomized controlled trials evaluating the effects of L-citrulline supplementation on blood pressure parameters. The meta-analysis concluded that L-citrulline supplementation significantly reduced both systolic and diastolic blood pressure, particularly in individuals with hypertension or prehypertension.

Neurological Disease Prevention:

The Role of Nitric Oxide:

Beyond its cardiovascular benefits, nitric oxide plays a crucial role in neurological function and disease prevention. Nitric oxide serves as a neurotransmitter in the central nervous system, where it modulates synaptic plasticity, neurotransmitter release, and cerebral blood flow. Dysfunction in the nitric oxide signalling pathway has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke.

Recent research has highlighted the neuroprotective properties of nitric oxide, suggesting its potential role in mitigating the risk of neurological diseases. By promoting cerebral vasodilation and enhancing blood flow to the brain, nitric oxide helps maintain optimal neuronal function and cognitive performance. Moreover, nitric oxide exhibits anti-inflammatory and antioxidant effects, which further contribute to neuroprotection and neuronal survival.

The synergistic actions of L-arginine and L-citrulline in enhancing nitric oxide production offer a promising avenue for neurological disease prevention. By supporting healthy vascular function and cerebral blood flow, these amino acids may help preserve cognitive function and reduce the risk of neurodegenerative disorders. Preliminary studies have demonstrated the neuroprotective effects of L-arginine and L-citrulline in animal models of neurological diseases, warranting further investigation into their therapeutic potential in humans.

In conclusion, the amino acids L-arginine and L-citrulline play integral roles in nitric oxide synthesis, contributing to cardiovascular health and neurological disease prevention. Through their vasodilatory effects, L-arginine and L-citrulline help lower systolic blood pressure and improve vascular function, reducing the risk of hypertension and cardiovascular events. Additionally, nitric oxide exerts neuroprotective effects, making it a potential target for mitigating the risk of neurological diseases. By harnessing the power of L-arginine and L-citrulline to enhance nitric oxide production, individuals may promote overall health and well-being while reducing the burden of cardiovascular and neurological disorders. However, further research is needed to elucidate the mechanisms underlying their therapeutic effects and optimize their clinical utility.

Metulas Supplements is a British brand committed to delivering top-quality amino acid-based Food Supplement Drink Mixes. A family-owned business that prides itself on its dedication to scientific research and product quality. Every formulation offered has been created by a team of expert nutritionists and scientists and every line of production undergoes rigorous test and quality control procedures, ensuring every tub meets the highest standards of efficacy and safety; and most importantly the formulations do what they say they are going to do! All Metulas Supplements Food Supplement Drink Mixes are made in the UK - a country recognised for its world class manufacturing. The team are committed to customer satisfaction and customer support. If you have any questions relating to any information in these blogs or would like to know more about the products of Metulas Supplements or have any questions at all - head over to and drop us a line!




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