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How can I help my recovery from Long COVID? (Part 1: Amino Acids)

Harnessing the Power of L-arginine and L-Citrulline: A Promising Approach to help support Long COVID Recovery.

Presented by Metulas Supplements.

Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as a complex and debilitating condition affecting individuals who have recovered from acute COVID-19.

Symptoms such as persistent fatigue, brain fog, shortness of breath, and muscle weakness can linger for weeks or months, significantly impacting the quality of life. While there is no definitive cure for long COVID, emerging evidence suggests that the amino acids L-arginine and L-citrulline may offer potential benefits in the management of this condition.

In this blog, we will explore how these amino acids work and their potential role in promoting recovery from long COVID.

Understanding L-arginine and L-Citrulline:

L-arginine and L-citrulline are amino acids that play crucial roles in various physiological processes. L-arginine is a precursor for nitric oxide (NO), a molecule that helps relax and dilate blood vessels, improving blood flow. L-citrulline, on the other hand, is converted into L-arginine in the body, thereby indirectly increasing NO production.

Enhancing Blood Flow and Oxygen Delivery:

One of the key mechanisms by which L-arginine and L-citrulline may benefit individuals with long COVID is by improving blood flow and oxygen delivery to tissues. Studies have shown that COVID-19 can cause endothelial dysfunction, leading to impaired blood vessel function. By increasing NO production, L-arginine and L-citrulline can help promote vasodilation, reducing vascular resistance and enhancing blood flow to organs and tissues. This increased blood flow can support the healing process, alleviate fatigue, and improve exercise tolerance.

Boosting Immune Function:

Long COVID is often associated with persistent immune dysregulation, characterized by chronic inflammation and immune system imbalances. L-arginine and L-citrulline have been shown to modulate immune responses, promoting a balanced and coordinated immune system. Additionally, these amino acids have been reported to enhance the production and activity of immune cells, such as T-cells and natural killer (NK) cells, which play a crucial role in combating viral infections. By supporting immune function, L-arginine and L-citrulline may aid in the resolution of inflammation and promote a faster recovery from long COVID.

Mitigating Oxidative Stress:

Oxidative stress, an imbalance between free radicals and antioxidants in the body, is implicated in the pathogenesis of long COVID. L-arginine and L-citrulline possess antioxidant properties and can help scavenge harmful free radicals, reducing oxidative stress. By mitigating oxidative damage, these amino acids may contribute to the healing process and alleviate symptoms associated with long COVID, such as brain fog and muscle weakness.

Supporting Energy Production:

Chronic fatigue is one of the hallmark symptoms of long COVID, affecting individuals' daily activities and quality of life. L-arginine and L-citrulline are involved in the production of adenosine triphosphate (ATP), the primary energy currency of cells. By enhancing ATP synthesis, these amino acids can provide a sustainable energy source for cells, potentially alleviating fatigue and promoting recovery.


While the management of long COVID remains multifaceted and requires a holistic approach, emerging evidence suggests that L-arginine and L-citrulline may have potential benefits in supporting recovery from this condition. By enhancing blood flow, modulating immune function, reducing oxidative stress, and supporting energy production, these amino acids offer a promising avenue for addressing the persistent symptoms experienced by individuals with long COVID. Arterial Formulation, made by Metulas Supplements, contains 5g of L-Arginine and 1g of L-Citrulline in every 10g serving scoop. However, it is important to note that further research is needed.

Metulas Supplements is a British brand committed to delivering top-quality amino acid-based Food Supplement Drink Mixes. A family-owned business that prides itself on its dedication to scientific research and product quality. Every formulation offered has been created by a team of expert nutritionists and scientists and every line of production undergoes rigorous test and quality control procedures, ensuring every tub meets the highest standards of efficacy and safety; and most importantly the formulations do what they say they are going to do! All Metulas Supplements Food Supplement Drink Mixes are made in the UK - a country recognised for its world class manufacturing. The team are committed to customer satisfaction and customer support. If you have any questions relating to any information in these blogs or would like to know more about the products of Metulas Supplements or have any questions at all - head over to and drop a line!


Arterial Formulation L-Arginine Vitamin Drink Mix

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